Diabetes, the "sweet killer" that troubles over 400 million people worldwide, is now facing an unprecedented treatment revolution.

The core pathological feature of Parkinson's disease is the significant and progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain and their projections in the striatum.

The research team has revealed that a gene recently identified as a biomarker for Alzheimer's disease (AD) - PHGDH - is actually the key cause of the disease due to its previously unknown "moonlighting role".

This study systematically reveals for the first time that "gut bacteria - bile acids - gut FXR-GLP-1 - articular cartilage axis" plays an important role in OA.

The research team built a stem cell factory with a specific culture program to achieve high-throughput production of human mitochondria, providing a new solution for the treatment of osteoarthritis.

The research team conducted a comprehensive investigation of umbilical cord mesenchymal stromal cell (UC-MSC) -derived exosomes (SEVs) with the help of a variety of in vitro and in vivo experiments.

The research article provides a breakthrough theoretical basis to completely solve this problem that has plagued the development of the industry for a long time.

The study presents preclinical data on the safety and efficacy of autologous cell therapy based on human induced pluripotent stem cells (hiPSC) for Parkinson's disease, on which a clinical trial will be conducted in eight patients with Parkinson's disease.