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Shanghai YuanVore Medical Technology Co., Ltd. is dedicated to the development and application of iPSC (induced pluripotent stem cell) technology. The core leadership team of the company has mature experience in the transformation and industrialization of biomedicine technology, and aims to establish a presence both domestically and globally. We are committed to cutting-edge research and development in the fields of neurology, immunology, and metabolism, focusing on stem cell and gene therapy. Our mission is to alleviate the suffering of patients and create an influential specialized technological enterprise.
If you are a responsible and dedicated individual, a kind and excellent young person, an active member who loves life and work, and an ambitious and aspiring youth, Yuanvore Medical is willing to offer you a platform to showcase your talent and realize your value! Here, you will have a free and open research atmosphere, as well as the opportunity to rapidly improve your professional abilities. Join us, and all your desires and accomplishments can become a reality! The following positions are available, Welcome to send your resume!
The following positions are welcome to take corresponding seats！
1. Responsible for the development of iPSC-related techniques, participate in the research and optimization of iPSC proliferation and differentiation techniques, and contribute to the development, scale-up, and validation of iPSC production processes.
2. Responsible for cell preparation, culture, cryopreservation, and revival, as well as other related cellular experiments and cell biology.
3. Develop SOPs for stem cell preparation processes and complete process transfers.
4. Conduct research, project planning, and feasibility analysis, collect scientific evidence for product development, provide relevant technical indicators, and establish project research plans and organize implementation.
5. Organize and analyze experimental data and results, write project reports.
6. Draft standard operating procedures, technical patents, project proposals, and other related documents for new products, as well as publish research papers./span>
7. Report research and development progress in a timely manner and complete other tasks assigned by superiors.
1. PhD or above in biomedical sciences, cell biology, or related fields; with research experience in stem cells.
2. Proficient in molecular and cell biology, with at least 3 years of experience working with iPSCs/ESCs/MSCs.
3. Familiar with molecular biology techniques and stem cell culture.
4. Strong literature search and English and Chinese writing skills, proficient in commonly used biological software and databases.
5. Possess scientific research and innovative abilities, able to creatively solve various problems in scientific experiments.
1. Responsible for the development and optimization of pilot/pilot scale stem cell culture and differentiation processes for ongoing research projects, including process design, batch records and preparation of SOP documents.
2. Cooperate with QA and purchasing departments to complete GMP workshop design, layout, equipment procurement and verification, etc., and be responsible for organizing and compiling GMP documents and declaration-related materials and other documents.
3. Cooperate with QA and registration departments to prepare relevant CMC documents, complete clinical application work, and pass CFDA on-site verification.
4. Assist in the implementation of technology transfer and complete process confirmation on the company's GMP production platform.
5. Responsible for the maintenance and management of relevant instruments and equipment in the workshop.
6. Build a team and be responsible for daily management, personnel training and technical development.
7. Other related matters arranged by the company.
1. PMajor in biopharmaceuticals, master's degree or above, five years or above working experience in technical positions, and more than two years of management experience.
2. A profound theoretical knowledge system of biopharmaceutical, and the direction of animal cell and microbial fermentation.
3. Experience in pilot test or GMP production management, and experience in clinical application or clinical sample production.
4. Years of experience in disposable reactor operation and application.
5. Adhering cell culture experts, including laboratory process development and large-scale culture.
6. DoE process development experts who can independently complete process development in line with QbD concepts.
7. Good team leadership skills, communication and expression skills.
1. Conduct background research and develop development plans based on company product development needs.
2. Establish a stem cell functional analysis detection technology platform and conduct new technology and product reserves.
3. Responsible for the development, transfer, and validation of cell-related cytological testing methods for cell products, and draft corresponding documents.
4. Engage in technical problem-solving for stem cell functional analysis detection methods, complete problem-solving tasks and technical summaries, ensuring the scientificity, rationality, and data reliability of the research process.
5. Responsible for flow cytometric analysis of clinical samples, copy number analysis, cytokine detection, and sample storage and retrieval.
6. Responsible for the processing of relevant experimental data, SOPs, research plans and reports, as well as experimental records.
7. Timely summarize and organize experimental results and report to superiors.
8. Participate in the development projects for scientific research and application transformation, assist in publishing scientific research papers, and protect intellectual property rights.
1. Postgraduate degree or above in immunology, clinical medicine, biochemistry, molecular biology, or cell biology, etc. Previous experience is preferred.
2. Familiar with cell biology detection work, including cell viability assays, FACS-based detection methods, cell phenotyping, functional activity assays, cell cytokines, mycoplasma, process impurities residual, titer detection, and other laboratory techniques. Excellent problem-solving skills, mastery of experimental design and data analysis knowledge, able to independently design experiments, analyze data, and write experimental reports.
3. Strong English proficiency, good English reading and writing abilities, capable of conducting literature research and writing SCI articles.
4. Strong execution ability, good teamwork skills, and certain ability to work under pressure.
5. Passionate about laboratory work, strong experimental skills, and ability to analyze and solve problems. Strong sense of responsibility and patience.
1. Develop, train, and optimize a variety of machine learning models, including cutting-edge machine learning, deep learning, and Transformer-based models, for identifying inhibitors and activators for specific targets.
2. Perform data preprocessing, feature engineering and model tuning.
3.Processing and analyzing large libraries of small molecule compounds for high throughput virtual screening.
4. Work with interdisciplinary teams to evaluate and validate screening results.
5. Prepare technical reports and present research results.
6. Keep track of the latest advances in machine learning technology and bioinformatics to improve project efficiency and effectiveness.
7. Explore and implement the improvement of algorithm effect and business process optimization of AI model in pharmaceutical research and development application.
1. Master's degree (or equivalent work experience) in computer science, artificial intelligence, bioinformatics, computational chemistry/biology, data science, or related field.
2. Proficient in Python, experience in machine learning and deep learning model training, especially model training based on Transformer architecture.
3. Familiar with Scikit-learn, TensorFlow, and PyTorch.
4. Strong interest in emerging technologies and algorithms.
5. Fast learning ability, good team work and communication skills, and excellent problem solving skills, able to communicate and cooperate effectively in multi-disciplinary teams.
1. Be fully responsible for the establishment of the company's quality system and the implementation of the company's GMP system to ensure that all activities within the drug life cycle such as drug research and development, production, and inspection comply with the requirements of domestic and foreign regulations.
2. Manage and guide QC verification work to ensure that the company's quality management assurance system meets the requirements of international (FDA, EMA, PIC/S, ICH, etc.) and domestic (NMPA) regulations.
3. Review/approve quality-related documents such as standard operating procedures, deviation reports, stability study plans/reports, entrusted production/inspections, and instrument/equipment monitoring and maintenance plans.
4. Responsible for reviewing the release of materials and products to ensure compliance with the release procedures; responsible for evaluating and approving material suppliers, and responsible for supplier management and formulating annual supplier audit plans.
5. Responsible for organizing self-inspection and receiving official/customer external audits, coordinating with various departments of the company to cooperate with inspections, and implementing rectification of non-conformities;.
6. Organize the preparation of quality-related materials required for clinical research applications; conduct regulatory compliance review of registration-related documents to ensure that drug registration-related documents comply with regulatory requirements.
7. Responsible for communication on quality-related government affairs and establishing good working relationships.
1. Bachelor degree or above in biomedicine related majors.
2. More than 5 years of experience in drug production quality, including more than 3 years of experience in quality management positions.
3. Working experience in a cell drug or preparation manufacturing company is preferred.
4. Be familiar with medicine-related laws and regulations and put them into work.
5. Good communication, organizational and coordination skills, and team management skills.
6. Strong sense of responsibility, active and rigorous work.